研究组

党云琨

1995.9-1999.6,中国农业大学理学学士学位;1999.9-2002.7,中国农业大学理学硕士学位;2003.9-2009.12,加拿大University of British Columbia博士学位;2010.4-2017.9,美国University of Texas Southwestern Medical Center,博士后、讲师;2017.10-,太阳成集团tyc7111cc生命科学中心,研究员。


主要研究方向

结合生物信息学和生化分子生物学,研究表观遗传和转录调控,专注于下列两个方面问题:

1DNA甲基化等表观遗传修饰的发生和调控机制,以及在发育和疾病中起着关键的作用。

2,密码子偏好性对于基因在转录和翻译层面的调控,为同义突变引起的疾病提供理论基础。


  1. Jingjing Fu, Yunkun Dang, Christopher Counter, Yi Liu, Codon usage regulates human KRAS expression at both transcriptional and translational levels. Journal of Biological Chemistry (2018) 293: 17929-17940.

  2. Zhipeng Zhou#, Yunkun Dang#*, Mian Zhou, Haiyan Yuan, Yi Liu*, Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation. Elife (2018) 7:e33569

  3. Xiao Liu, Yunkun Dang, Toru Matsu-ura, Yubo He, Qun He, Christian I. Hong, Yi Liu, DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition. Molecular Cell (2017) 67:1-11

  4. Yunkun Dang#, Jiasen Cheng# , Xianyun Sun, Zhipeng Zhou, Yi Liu. Antisense transcription licenses nascent transcripts to be recognized by ERI-1 to mediate transcriptional gene silencing. Genes & Development, (2016) 30:2417-32.

  5. Zhipeng Zhou#, Yunkun Dang#, Mian Zhou, Lin Li, Chien-Hung Yu, Jingjing Fu, She Chen, and Yi Liu. Codon Usage is an Important Determinant of Gene Expression Levels Largely Through its Effects on Transcription. PNAS (2016) E6117-E6125.

  6. Chien-hung Yu#, Yunkun Dang#, Zhipeng Zhou#, Cheng Wu, Fangzhou Zhao, Matthew S. Sashs, Yi Liu. Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding. Molecular Cell (2015) 59:744-54Cover articlespecial comment in Trend Biochem Sci (2015) 40:717-8

  7. Yunkun Dang, Liande Li, Wei Guo, Zhihong Xue, Yi Liu. Convergent transcription induces dynamic DNA methylation at disiRNA loci. PLoS Genetics (2013) 9(9): e1003761

  8. Chang Ying Teng, Yunkun Dang, Jillian C. Danne, Ross F. Waller, Beverley R. Green. Genes of Dinoflagellates Are Transcribed by a Nuclear-Encoded Single-Subunit RNA Polymerase. PLoS One (2013) DOI: 10.1371/journal.pone.0065387

  9. Yunkun Dang, Qiuying Yang, Zhihong Xue, Yi Liu. RNA interference in fungi: pathways, functions, and applications. Eukaryotic Cell (2011) 10: 1148-1155

  10. Yunkun Dang, Beverley R. Green, Long transcripts from din...

办公室:

太阳成集团tyc7111cc呈贡区太阳成集团tyc7111cc3栋3512室


EMAIL:

ykdang@ynu.edu.cn

yunkun_dang@126.com